Description

3-(4-Methylphenyl)-3',4',5'-Trifluoropropiophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring a trifluorinated phenyl ring and a propiophenone core, makes it a valuable precursor for the development of complex pharmaceutical intermediates and agrochemicals. This compound is primarily utilized by R&D chemists and process development scientists in the fine chemical and life science industries seeking to introduce specific fluorinated motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl and fluorine substituents can improve efficacy and environmental profile.
• Liquid Crystal & OLED Material Research: Used in the synthesis of fluorinated organic compounds for electronic applications, including liquid crystal displays and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Acts as a monomer or modifier in the production of specialty polymers with tailored thermal, chemical, or optical properties.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct more complex biaryl structures.
• Chemical Research & Development: Employed in academic and industrial labs for method development and exploring new synthetic pathways involving fluorinated ketones.

Basic Information

Product Name	3-(4-Methylphenyl)-3',4',5'-Trifluoropropiophenone
CAS No.	898769-43-2
Molecular Formula	C16H13F3O
Molecular Weight	278.27 g/mol
Synonyms	1-[3,4,5-Trifluorophenyl]-3-(4-methylphenyl)-1-propanone; 3-(p-Tolyl)-1-(3,4,5-trifluorophenyl)propan-1-one; 3',4',5'-Trifluoro-3-(4-methylphenyl)propiophenone; 3-(4-Methylphenyl)-1-(3,4,5-trifluorophenyl)propan-1-one; 1-Propanone, 1-(3,4,5-trifluorophenyl)-3-(4-methylphenyl)-; 3-(4-Methylphenyl)-3,4,5-trifluoropropiophenone
EINECS	Contact for details

Quality Control

Our 3-(4-Methylphenyl)-3',4',5'-Trifluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from techniques including HPLC, GC, NMR, and mass spectrometry. Our quality commitment ensures the material meets the stringent requirements for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.