Description

2',4'-Difluoro-3-(4-Methylphenyl)Propiophenone is a high-purity fluorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, where its specific difluoro and methylphenyl substitution pattern offers unique reactivity and properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides, leveraging the stability imparted by the fluorine atoms.
• Material Science: Used in the research and development of specialty polymers and liquid crystals, where fluorinated aromatic units enhance thermal stability and optical properties.
• Organic Synthesis: A versatile reagent for constructing complex molecular architectures via reactions such as Friedel-Crafts acylation, reduction, or nucleophilic addition, facilitated by the propiophenone backbone.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation in pharmaceutical or chemical manufacturing.

Basic Information

Product Name	2',4'-Difluoro-3-(4-Methylphenyl)Propiophenone
CAS No.	898769-34-1
Molecular Formula	C16H14F2O
Molecular Weight	260.28 g/mol
Synonyms	1-(2,4-Difluorophenyl)-3-(p-tolyl)propan-1-one; 3-(4-Methylphenyl)-1-(2,4-difluorophenyl)propan-1-one; 2,4-Difluoro-3'-(4-methylphenyl)propiophenone; 3-(4-Methylphenyl)-2',4'-difluoropropiophenone; p-Methyl-2',4'-difluoropropiophenone
EINECS	Contact for details

Quality Control

Our 2',4'-Difluoro-3-(4-Methylphenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.