Description

4'-Chloro-2'-Fluoro-3-(4-Methylphenyl)Propiophenone is a high-value fluorinated and chlorinated aromatic ketone intermediate, distinguished by its unique substitution pattern. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, offering chemists precise control over molecular architecture. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers developing new active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in therapeutic areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the chloro-fluoro-phenyl moiety contributes to efficacy and selectivity.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating specialized organic molecules used in electronic displays and photonic devices.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for client-specific, multi-step synthetic routes.
• Academic & Industrial R&D: Utilized in research laboratories for methodological studies in cross-coupling reactions and fluorination chemistry.
• Fine Chemical Production: Intermediate for manufacturing other complex specialty chemicals, including dyes, pigments, and functional polymers.

Basic Information

Product Name	4'-Chloro-2'-Fluoro-3-(4-Methylphenyl)Propiophenone
CAS No.	898769-16-9
Molecular Formula	C16H14ClFO
Molecular Weight	276.73 g/mol
Synonyms	1-(4-Chloro-2-fluorophenyl)-3-(p-tolyl)propan-1-one; 3-(4-Methylphenyl)-1-(4-chloro-2-fluorophenyl)propan-1-one; 4'-Chloro-2'-fluoro-3-(p-tolyl)propiophenone; 1-Propanone, 1-(4-chloro-2-fluorophenyl)-3-(4-methylphenyl)-; p-Tolyl 4-chloro-2-fluorobenzyl ketone derivative
EINECS	Contact for details

Quality Control

Every batch of 4'-Chloro-2'-Fluoro-3-(4-Methylphenyl)Propiophenone is produced under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency that meets the stringent requirements of pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.