Description

3'-Chloro-5'-Fluoro-3-(4-Methylphenyl)Propiophenone is a high-purity fluorinated and chlorinated aromatic ketone building block, essential for advanced organic synthesis. Its precise molecular architecture makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular frameworks.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of new drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorine and chlorine substituents enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in display and lighting technologies.
• Cross-Coupling Reactions: Utilized in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: Employed in academic and industrial labs for methodological studies in fluorination chemistry and asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) producing bespoke compounds for client projects.

Basic Information

Product Name	3'-Chloro-5'-Fluoro-3-(4-Methylphenyl)Propiophenone
CAS No.	898769-13-6
Molecular Formula	C16H14ClFO
Molecular Weight	276.73 g/mol
Synonyms	1-(3-Chloro-5-fluorophenyl)-3-(p-tolyl)propan-1-one; 3-(4-Methylphenyl)-1-(3-chloro-5-fluorophenyl)propan-1-one; 3'-Chloro-5'-fluoro-3-(p-tolyl)propiophenone; Propiophenone, 3'-chloro-5'-fluoro-3-(4-methylphenyl)-; 1-(3-Chloro-5-fluorophenyl)-3-(4-methylphenyl)-1-propanone
EINECS	Contact for details

Quality Control

Our 3'-Chloro-5'-Fluoro-3-(4-Methylphenyl)Propiophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with full traceability are provided for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.