Description

2'-Chloro-4'-Fluoro-3-(4-Methylphenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate with the CAS number 898769-10-3. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and inflammatory pathways. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing new therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel API candidates, especially for neurological and anti-inflammatory applications.
• Organic Synthesis Building Block: Used in research-scale and pilot-scale reactions to introduce specific halogenated aryl ketone motifs into more complex molecular architectures.
• Medicinal Chemistry Research: Employed in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Fine Chemical Production: Serves as a starting material or intermediate in the manufacture of specialty chemicals, agrochemicals, and performance materials.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring high-purity, bespoke intermediates.

Basic Information

Product Name	2'-Chloro-4'-Fluoro-3-(4-Methylphenyl)Propiophenone
CAS No.	898769-10-3
Molecular Formula	C₁₆H₁₄ClFO
Molecular Weight	276.74 g/mol
Synonyms	1-(2-Chloro-4-fluorophenyl)-3-(p-tolyl)propan-1-one; 3-(4-Methylphenyl)-1-(2-chloro-4-fluorophenyl)propan-1-one; 2'-Chloro-4'-fluoro-3-(p-tolyl)propiophenone; 898769-10-3; Propiophenone, 2'-chloro-4'-fluoro-3-(4-methylphenyl)-; 1-(2-Chloro-4-fluorophenyl)-3-(4-methylphenyl)-1-propanone
EINECS	Contact for details

Quality Control

Our 2'-Chloro-4'-Fluoro-3-(4-Methylphenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.