Description

3'-Chloro-4'-Fluoro-3-(4-Methylphenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its precise molecular architecture enables targeted therapeutic effects. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in developing new drug candidates, particularly in areas requiring sophisticated fluorinated and chlorinated motifs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug molecules, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• API Synthesis: Used as a key building block for constructing the core scaffold of potential Active Pharmaceutical Ingredients (APIs) with fluorinated and chlorinated aryl groups.
• Medicinal Chemistry Research: Employed in research and development (R&D) laboratories for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Production: Utilized in the custom synthesis of complex, high-value specialty chemicals for advanced material science and agrochemical research.
• Contract Manufacturing: Supplied to Contract Development and Manufacturing Organizations (CDMOs) for cGMP-compliant production of clinical trial materials and commercial APIs.

Basic Information

Product Name	3'-Chloro-4'-Fluoro-3-(4-Methylphenyl)Propiophenone
CAS No.	898768-93-9
Molecular Formula	C16H14ClFO
Molecular Weight	276.73 g/mol
Synonyms	1-(3-Chloro-4-fluorophenyl)-3-(p-tolyl)propan-1-one; 3-(4-Methylphenyl)-1-(3-chloro-4-fluorophenyl)propan-1-one; 3'-Chloro-4'-fluoro-3-(p-tolyl)propiophenone; 3-(4-Methylphenyl)-1-(3-chloro-4-fluorophenyl)-1-propanone; Propiophenone, 3'-chloro-4'-fluoro-3-(4-methylphenyl)-; 1-Propanone, 1-(3-chloro-4-fluorophenyl)-3-(4-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 3'-Chloro-4'-Fluoro-3-(4-Methylphenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.