Description

2',6'-Dichloro-3-(4-Fluorophenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound is of significant commercial importance for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions and other advanced organic transformations to introduce the dichloro-fluorophenyl moiety into more complex molecular architectures.
• Research & Development (R&D): Essential for medicinal chemistry programs in academic, government, and industrial laboratories for structure-activity relationship (SAR) studies.
• Process Chemistry: Used in scale-up and optimization studies for the commercial production of target APIs, ensuring robust and reproducible synthetic routes.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	2',6'-Dichloro-3-(4-Fluorophenyl)Propiophenone
CAS No.	898768-84-8
Molecular Formula	C15H11Cl2FO
Molecular Weight	297.15 g/mol
Synonyms	1-(2,6-Dichlorophenyl)-3-(4-fluorophenyl)propan-1-one; 3-(4-Fluorophenyl)-1-(2,6-dichlorophenyl)-1-propanone; 2,6-Dichloro-3-(4-fluorophenyl)propiophenone; Propiophenone, 2',6'-dichloro-3-(4-fluorophenyl)-; 898768-84-8; 3-(4-Fluorophenyl)-1-(2,6-dichlorophenyl)propan-1-one
EINECS	Contact for details

Quality Control

Our 2',6'-Dichloro-3-(4-Fluorophenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and current industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.