Description

3',4'-Difluoro-3-(4-Fluorophenyl)Propiophenone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its precise molecular architecture, featuring multiple fluorine substitutions, makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and specialty materials. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorinated motifs for enhanced bioactivity and stability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and CNS-active molecule libraries.
• Agrochemical Synthesis: Used in the preparation of advanced fluorinated herbicides and pesticides, where fluorine atoms improve metabolic stability and membrane permeability.
• Material Science Precursor: Serves as a building block for synthesizing specialty polymers and liquid crystals with tailored electronic and optical properties.
• Chemical Research: Employed in academic and industrial laboratories for method development in cross-coupling reactions and fluorination chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.

Basic Information

Product Name	3',4'-Difluoro-3-(4-Fluorophenyl)Propiophenone
CAS No.	898768-78-0
Molecular Formula	C15H11F3O
Molecular Weight	264.24 g/mol
Synonyms	1-(3,4-Difluorophenyl)-3-(4-fluorophenyl)propan-1-one; 3-(4-Fluorophenyl)-1-(3,4-difluorophenyl)propan-1-one; 3',4'-Difluoro-3-(4-fluorophenyl)propiophenone; 898768-78-0; 3-(4-Fluorophenyl)-1-(3,4-difluorophenyl)-1-propanone; Propiophenone, 3',4'-difluoro-3-(4-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our 3',4'-Difluoro-3-(4-Fluorophenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.