Description

3-(4-Fluorophenyl)-2'-Trifluoromethylpropiophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals, where its unique trifluoromethyl and fluorophenyl groups impart desirable biological and physicochemical properties. It is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce fluorinated motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the fluorine atoms for enhanced efficacy and environmental profile.
• Material Science Research: Serves as a building block for fluorinated liquid crystals, polymers, and organic electronic materials.
• Chemical Biology Probes: Employed in the design of fluorinated probes and tags for studying biological mechanisms and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Industrial R&D: Utilized in methodological research for new fluorination techniques and cross-coupling reactions.

Basic Information

Product Name	3-(4-Fluorophenyl)-2'-Trifluoromethylpropiophenone
CAS No.	898768-56-4
Molecular Formula	C16H12F4O
Molecular Weight	296.26 g/mol
Synonyms	1-[3-(4-Fluorophenyl)propyl]-2-(trifluoromethyl)benzene; 3-(4-Fluorophenyl)-1-[2-(trifluoromethyl)phenyl]-1-propanone; 2'-Trifluoromethyl-3-(p-fluorophenyl)propiophenone; 3-(4-Fluorophenyl)-2'-(trifluoromethyl)propiophenone; Propiophenone, 3-(4-fluorophenyl)-2'-(trifluoromethyl)-; α,α,α-Trifluoro-2'-[3-(4-fluorophenyl)propionyl]toluene; 4-Fluoro-β-[2-(trifluoromethyl)benzoyl]ethylbenzene
EINECS	Contact for details

Quality Control

Our 3-(4-Fluorophenyl)-2'-Trifluoromethylpropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where required, ensuring suitability for demanding applications in pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.