Description

4'-Chloro-3'-Fluoro-3-(4-Fluorophenyl)Propiophenone is a high-purity fluorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. This compound is valued for its precise molecular architecture, which serves as a critical building block in the development of complex active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to introduce specific halogenated motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the fluorinated phenyl groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic semiconductors.
• Cross-Coupling Reactions: Functions as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems.
• Chemical Research & Development: Employed in academic and industrial labs for method development and exploring new reaction pathways involving halogenated ketones.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical custom manufacturers producing tailored intermediates for client-specific projects.

Basic Information

Product Name	4'-Chloro-3'-Fluoro-3-(4-Fluorophenyl)Propiophenone
CAS No.	898768-46-2
Molecular Formula	C15H11ClF2O
Molecular Weight	280.70 g/mol
Synonyms	1-(4-Chloro-3-fluorophenyl)-3-(4-fluorophenyl)propan-1-one; 3-(4-Fluorophenyl)-1-(4-chloro-3-fluorophenyl)propan-1-one; 4'-Chloro-3'-fluoro-3-(4-fluorophenyl)propiophenone; 898768-46-2; Propiophenone, 4'-chloro-3'-fluoro-3-(4-fluorophenyl)-; 3-(4-Fluorophenyl)-1-(4-chloro-3-fluorophenyl)-1-propanone
EINECS	Contact for details

Quality Control

Our 4'-Chloro-3'-Fluoro-3-(4-Fluorophenyl)Propiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.