Description

2',4'-Difluoro-3-(3-Methylphenyl)Propiophenone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its precise molecular structure makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecules with targeted properties.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where the difluoro and methylphenyl groups impart specific biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Chemical Research & Development: A versatile synthon for academic and industrial research involving Suzuki-Miyaura, Heck, and other cross-coupling reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.

Basic Information

Product Name	2',4'-Difluoro-3-(3-Methylphenyl)Propiophenone
CAS No.	898768-16-6
Molecular Formula	C16H14F2O
Molecular Weight	260.28 g/mol
Synonyms	1-(2,4-Difluorophenyl)-3-(3-methylphenyl)propan-1-one; 3-(3-Methylphenyl)-1-(2,4-difluorophenyl)-1-propanone; 2,4-Difluoro-3'-(3-methylphenyl)propiophenone; 3'-Methyl-2,4-difluoropropiophenone; 898768-16-6; Propiophenone, 2',4'-difluoro-3-(3-methylphenyl)-; 1-Propanone, 1-(2,4-difluorophenyl)-3-(3-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 2',4'-Difluoro-3-(3-Methylphenyl)Propiophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment. Our quality commitment supports compliance with ICH Q7 guidelines and customer-specific requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider storing under an inert atmosphere such as nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.