Description

3-(4-Fluorophenyl)-4'-Thiomethylpropiophenone is a high-purity fluorinated aromatic ketone derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its value lies in its unique molecular structure, which incorporates both fluorine and sulfur-containing functional groups, enabling precise modifications for developing novel active compounds. This intermediate is essential for research and production in the pharmaceutical and agrochemical sectors, particularly for creating molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic small molecules.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the fluorophenyl moiety can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a monomer or precursor in the synthesis of specialized polymers and liquid crystals with specific optical or electronic properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, such as Suzuki or Heck reactions, and for introducing the thiomethyl group into complex molecular architectures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries for high-throughput screening.

Basic Information

Product Name	3-(4-Fluorophenyl)-4'-Thiomethylpropiophenone
CAS No.	898768-11-1
Molecular Formula	C16H15FOS
Molecular Weight	274.35 g/mol
Synonyms	1-[4-(Methylthio)phenyl]-3-(4-fluorophenyl)-1-propanone; 3-(4-Fluorophenyl)-1-[4-(methylsulfanyl)phenyl]propan-1-one; 4'-Methylthio-3-(4-fluorophenyl)propiophenone; 898768-11-1; Propiophenone, 3-(4-fluorophenyl)-4'-(methylthio)-; 3-(p-Fluorophenyl)-4'-(methylthio)propiophenone
EINECS	Contact for details

Quality Control

Our 3-(4-Fluorophenyl)-4'-Thiomethylpropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.