Description

4-(2-Iodophenyl)-4-Oxobutyronitrile is a versatile iodinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines an electron-withdrawing nitrile group with a halogenated aromatic ring, making it a valuable precursor for constructing complex heterocycles and pharmaceutical intermediates. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in cross-coupling reactions, ligand synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of novel herbicides and fungicides, leveraging the iodine atom for further functionalization.
• Material Science Precursor: Acts as a building block for organic electronic materials, such as non-linear optical (NLO) chromophores and charge-transport molecules.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to form biaryl structures.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the synthesis of tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	4-(2-Iodophenyl)-4-Oxobutyronitrile
CAS No.	898768-01-9
Molecular Formula	C10H8INO
Molecular Weight	285.08 g/mol
Synonyms	4-(2-Iodobenzoyl)butyronitrile; 4-Oxo-4-(2-iodophenyl)butanenitrile; 2-Iodobenzoylacetonitrile; γ-Oxo-2-iodobenzene butyronitrile; 4-(2-Iodobenzoyl)butyronitrile; Butyronitrile, 4-(2-iodobenzoyl)-; 1-(2-Iodophenyl)-4-cyanobutan-1-one
EINECS	Contact for details

Quality Control

Our 4-(2-Iodophenyl)-4-Oxobutyronitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles. Our commitment to quality supports your research and development needs with reliable, specification-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.