Description

3'-Chloro-5'-Fluoro-3-(3-Fluorophenyl)Propiophenone is a high-purity, fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of complex, biologically active molecules, particularly within pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into their target structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the difluoro and chloro substituents enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel fluorinated polymers and liquid crystals, where its structure can influence material properties like thermal stability and dielectric constant.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes.
• Academic and Industrial R&D: A valuable reagent for methodological studies in organic chemistry, particularly in halogenation and fluorination chemistry research.

Basic Information

Product Name	3'-Chloro-5'-Fluoro-3-(3-Fluorophenyl)Propiophenone
CAS No.	898767-53-8
Molecular Formula	C15H11ClF2O
Molecular Weight	280.70 g/mol
Synonyms	1-(3-Chloro-5-fluorophenyl)-3-(3-fluorophenyl)-1-propanone; 3-Chloro-5-fluoro-3'-(fluorophenyl)propiophenone; 3'-Chloro-5'-fluoro-3-(3-fluorophenyl)propiophenone; 3-(3-Fluorophenyl)-1-(3-chloro-5-fluorophenyl)propan-1-one; Propiophenone, 3'-chloro-5'-fluoro-3-(3-fluorophenyl)-; 898767-53-8; 3'-Chloro-5'-fluoro-3-(3-fluorophenyl)propiophenone
EINECS	Contact for details

Quality Control

Our 3'-Chloro-5'-Fluoro-3-(3-Fluorophenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen to prevent degradation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.