Description

4-(3,5-Difluorophenyl)-2,2-Dimethyl-4-Oxobutyric Acid is a high-purity fluorinated organic building block of significant importance in advanced chemical synthesis. This compound serves as a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its difluorophenyl moiety imparts desirable metabolic stability and bioavailability. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in cutting-edge R&D and production.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly in oncology, CNS, and metabolic disease research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides that require fluorinated aromatic structures for enhanced efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.
• Academic & Industrial R&D: Utilized in exploratory chemistry for creating novel chemical entities with potential biological activity.

Basic Information

Product Name	4-(3,5-Difluorophenyl)-2,2-Dimethyl-4-Oxobutyric Acid
CAS No.	898766-68-2
Molecular Formula	C12H12F2O3
Molecular Weight	242.22 g/mol
Synonyms	4-(3,5-Difluorophenyl)-2,2-dimethyl-4-oxobutanoic acid; 2,2-Dimethyl-4-(3,5-difluorophenyl)-4-oxobutyric acid; 4-Oxo-4-(3,5-difluorophenyl)-2,2-dimethylbutyric acid; Butyric acid, 4-(3,5-difluorophenyl)-2,2-dimethyl-4-oxo-; 3,5-Difluorophenyl 2,2-dimethyl-4-oxobutyl ketone derivative
EINECS	Contact for details

Quality Control

Our production of 4-(3,5-Difluorophenyl)-2,2-Dimethyl-4-Oxobutyric Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) documenting all specifications are provided with every shipment. We operate under a quality system designed to meet the demands of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.