Description

2'-Chloro-2,2-Dimethyl-4'-Fluoropropiophenone is a high-purity, specialized organic intermediate featuring a unique halogenated propiophenone structure. This compound matters for its role as a critical building block in the synthesis of complex molecules, particularly in advanced pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to introduce specific halogenated motifs into their target compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially those requiring fluorinated and chlorinated aromatic ketone functionalities.
• Agrochemical Synthesis: Used in the preparation of advanced herbicide and pesticide candidates, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a precursor in the development of specialty polymers, liquid crystals, or organic electronic materials.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, Grignard reactions, and reductions to create more complex molecular architectures.

Basic Information

Product Name	2'-Chloro-2,2-Dimethyl-4'-Fluoropropiophenone
CAS No.	898766-45-5
Molecular Formula	C11H12ClFO
Molecular Weight	214.66 g/mol
Synonyms	4'-Fluoro-2'-chloro-2,2-dimethylpropiophenone; 1-(2-Chloro-4-fluorophenyl)-2,2-dimethylpropan-1-one; 2,2-Dimethyl-1-(2-chloro-4-fluorophenyl)propan-1-one; Propiophenone, 2'-chloro-2,2-dimethyl-4'-fluoro-; α,α-Dimethyl-2-chloro-4-fluoropropiophenone
EINECS	Contact for details

Quality Control

Our 2'-Chloro-2,2-Dimethyl-4'-Fluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.