Description

4'-Bromo-2,2-dimethyl-2'-fluoropropiophenone is a high-purity, specialized organic building block featuring a bromo and a fluoro substituent on its aromatic ring. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in the development of complex pharmaceutical molecules and agrochemicals. It is essential for researchers and manufacturers in the fine chemical, pharmaceutical R&D, and agrochemical sectors who require precise, high-quality intermediates for coupling reactions and structure-activity relationship studies.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the bromo-fluoro substitution pattern is beneficial.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and advanced organic materials.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Chemical Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.
• Academic & Industrial R&D: Employed in exploratory chemistry for drug discovery and the development of novel chemical entities.

Basic Information

Item	Details
Product Name	4'-Bromo-2,2-dimethyl-2'-fluoropropiophenone
CAS No.	898766-42-2
Molecular Formula	C11H12BrFO
Molecular Weight	259.12 g/mol
Synonyms	2'-Fluoro-4'-bromo-2,2-dimethylpropiophenone; 1-(4-Bromo-2-fluorophenyl)-2,2-dimethylpropan-1-one; 4'-Bromo-2'-fluoro-2,2-dimethylpropiophenone; α,α-Dimethyl-4-bromo-2-fluorophenyl methyl ketone; 2,2-Dimethyl-1-(4-bromo-2-fluorophenyl)propan-1-one; Propiophenone, 4'-bromo-2,2-dimethyl-2'-fluoro-; 898766-42-2
EINECS	Contact for details

Quality Control

Our 4'-Bromo-2,2-dimethyl-2'-fluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.