Description

4'-Chloro-2,2-Dimethyl-3'-Fluoropropiophenone is a high-purity, specialized organic intermediate featuring a halogenated aromatic ketone structure. This compound is critical for its role as a key building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries who require precise and reliable starting materials for novel active ingredient development.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Serves as a key building block for developing novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Used in the development of specialty polymers and advanced organic materials where its specific molecular architecture imparts desired properties.
• Organic Synthesis & Process Chemistry: Employed in academic and industrial laboratories for method development, catalysis studies, and the construction of complex molecular frameworks.
• Ligand & Catalyst Development: Acts as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	4'-Chloro-2,2-Dimethyl-3'-Fluoropropiophenone
CAS No.	898766-30-8
Molecular Formula	C11H12ClFO
Molecular Weight	214.66 g/mol
Synonyms	1-(4-Chloro-3-fluorophenyl)-2,2-dimethylpropan-1-one; 3'-Fluoro-4'-chloro-2,2-dimethylpropiophenone; 2,2-Dimethyl-1-(4-chloro-3-fluorophenyl)propan-1-one; 4-Chloro-3-fluoro-2,2-dimethylpropiophenone; α,α-Dimethyl-4-chloro-3-fluorobenzeneacetone; 898766-30-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 4'-Chloro-2,2-Dimethyl-3'-Fluoropropiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee it meets the stringent requirements for research and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.