Description

3',5'-Difluoro-2,2-Dimethylbutyrophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular structure, which incorporates both fluorine atoms and a sterically hindered dimethyl group, making it a versatile precursor for complex molecule construction. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring fluorinated aromatic motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the difluoro and hindered ketone groups can contribute to biological activity.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and advanced organic materials with specific electronic or surface properties.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands or organocatalysts for asymmetric synthesis applications.
• Chemical Biology Probes: Useful for synthesizing fluorinated probes and tags used in biochemical assays and imaging studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3',5'-Difluoro-2,2-Dimethylbutyrophenone
CAS No.	898766-06-8
Molecular Formula	C12H14F2O
Molecular Weight	212.24 g/mol
Synonyms	1-(3,5-Difluorophenyl)-2,2-dimethyl-1-propanone; 3,5-Difluoro-α,α-dimethylbenzenepropanal; 2,2-Dimethyl-1-(3,5-difluorophenyl)propan-1-one; 3,5-Difluoro-α,α-dimethylhydrocinnamaldehyde; Butyrophenone, 3',5'-difluoro-2,2-dimethyl-; DFDM Butyrophenone
EINECS	Contact for details

Quality Control

Our 3',5'-Difluoro-2,2-Dimethylbutyrophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP and ISO standards ensures reliable supply for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.