Description

3',4'-Difluoro-2,2-Dimethylbutyrophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring a difluorinated aromatic ring and a hindered butyrophenone moiety, makes it a valuable precursor for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by research chemists and process development scientists for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and other therapeutic areas where fluorination enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the difluoro and dimethyl groups can impart specific biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in advanced electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Polymer Science: Employed in the synthesis of specialty monomers for high-performance polymers, where the aromatic ketone functionality can be incorporated into polymer backbones or as a cross-linking agent.
• Organic Synthesis & Catalysis Research: Acts as a model substrate or a challenging motif in methodological development for novel fluorination, cross-coupling, and carbonyl chemistry.

Basic Information

Product Name	3',4'-Difluoro-2,2-Dimethylbutyrophenone
CAS No.	898766-04-6
Molecular Formula	C12H14F2O
Molecular Weight	212.24 g/mol
Synonyms	1-(3,4-Difluorophenyl)-2,2-dimethylbutan-1-one; 3,4-Difluoro-2,2-dimethylbutyrophenone; 2,2-Dimethyl-1-(3,4-difluorophenyl)butan-1-one; Butan-1-one, 1-(3,4-difluorophenyl)-2,2-dimethyl-; 3,4-DFDMBP; Difluorodimethylbutyrophenone
EINECS	Contact for details

Quality Control

Our 3',4'-Difluoro-2,2-Dimethylbutyrophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. For custom synthesis or specific purity requirements (e.g., >99.0%), please contact our technical sales team to discuss your project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.