Description

2',4'-Difluoro-2,2-Dimethylbutyrophenone is a high-purity, fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring a difluorophenyl moiety and a hindered tertiary butyl ketone, makes it a valuable precursor for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by research chemists and process development scientists for constructing active pharmaceutical ingredients (APIs) and other fine chemicals where fluorine substitution is critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Serves as a building block for developing new-generation herbicides, fungicides, and insecticides where the difluoro group enhances bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Used in the research and production of fluorinated organic electronic materials, contributing to improved performance in display and lighting technologies.
• Advanced Polymer Chemistry: Acts as a monomer or cross-linking agent precursor for synthesizing specialty polymers with unique thermal and chemical resistance properties.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	2',4'-Difluoro-2,2-Dimethylbutyrophenone
CAS No.	898766-02-4
Molecular Formula	C12H14F2O
Molecular Weight	212.24 g/mol
Synonyms	2,2-Dimethyl-1-(2,4-difluorophenyl)butan-1-one; 1-(2,4-Difluorophenyl)-2,2-dimethylbutan-1-one; 2,4-DFDMBP; α,α-Dimethyl-2,4-difluorohydrocinnamophenone; Butyrophenone, 2',4'-difluoro-2,2-dimethyl-; 2,2-Dimethyl-2,4-difluorobutyrophenone
EINECS	Contact for details

Quality Control

Every batch of 2',4'-Difluoro-2,2-Dimethylbutyrophenone is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed impurity profiling available. A comprehensive Certificate of Analysis (COA) is provided with each shipment, documenting identity, assay, and relevant physical parameters. We support cGMP compliance for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.