Description

4'-Chloro-2,2-Dimethyl-2'-Fluorobutyrophenone is a high-purity, fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Advanced Polymer Chemistry: Acts as a monomer or cross-linking agent in the development of specialty polymers with unique thermal and chemical resistance.
• Academic & Industrial R&D: Employed in methodological studies and scale-up processes for novel fluorination and coupling reactions.
• Fine Chemical Production: Integral to the custom synthesis of complex, high-value fluorinated aromatic compounds for various technological applications.

Basic Information

Product Name	4'-Chloro-2,2-Dimethyl-2'-Fluorobutyrophenone
CAS No.	898765-90-7
Molecular Formula	C12H14ClFO
Molecular Weight	228.69 g/mol
Synonyms	2'-Fluoro-4'-chloro-2,2-dimethylbutyrophenone; 1-(4-Chloro-2-fluorophenyl)-2,2-dimethyl-1-butanone; 4-Chloro-2-fluoro-α,α-dimethylbutyrophenone; Butyrophenone, 4'-chloro-2,2-dimethyl-2'-fluoro-; α,α-Dimethyl-4-chloro-2-fluorobutyrophenone; 2,2-Dimethyl-1-(4-chloro-2-fluorophenyl)butan-1-one
EINECS	Contact for details

Quality Control

Every batch of 4'-Chloro-2,2-Dimethyl-2'-Fluorobutyrophenone is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your internal quality protocols and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.