Description

4'-Bromo-2,2-dimethyl-2'-fluorobutyrophenone is a high-purity, fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring both bromo and fluoro substituents on an aromatic ring, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and pharmaceutical development companies engaged in the creation of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring fluorinated aromatic motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides, where the fluorine atom can improve biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Precursor: Employed in the research and development of advanced organic electronic materials and liquid crystals.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated intermediates.
• Academic & Industrial R&D: Utilized in exploratory chemistry for method development and creating novel chemical entities in both academic and corporate research laboratories.

Basic Information

Product Name	4'-Bromo-2,2-dimethyl-2'-fluorobutyrophenone
CAS No.	898765-84-9
Molecular Formula	C12H14BrFO
Molecular Weight	273.14 g/mol
Synonyms	2'-Fluoro-4'-bromo-2,2-dimethylbutyrophenone; 1-(4-Bromo-2-fluorophenyl)-2,2-dimethyl-1-butanone; 4'-Bromo-2'-fluoro-2,2-dimethylbutyrophenone; α,α-Dimethyl-4-bromo-2-fluorobutyrophenone; Butyrophenone, 4'-bromo-2,2-dimethyl-2'-fluoro-; 898765-84-9; 4-Bromo-2-fluoro-α,α-dimethylbutyrophenone
EINECS	Contact for details

Quality Control

Every batch of 4'-Bromo-2,2-dimethyl-2'-fluorobutyrophenone is produced and tested under a strict quality management system. We ensure high purity and batch-to-batch consistency through advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.