Description

2,2-Dimethyl-2'-Trifluoromethylbutyrophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoromethyl group, which is crucial for modulating the physicochemical properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the CF3 group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a building block for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with specific optical or electronic properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	2,2-Dimethyl-2'-Trifluoromethylbutyrophenone
CAS No.	898765-78-1
Molecular Formula	C13H15F3O
Molecular Weight	244.26 g/mol
Synonyms	α,α-Dimethyl-2'-(trifluoromethyl)butyrophenone; 1-[2-(Trifluoromethyl)phenyl]-2,2-dimethylpropan-1-one; 2,2-Dimethyl-1-(2-trifluoromethylphenyl)propan-1-one; 2'-Trifluoromethyl-2,2-dimethylbutyrophenone; TFMPB; Butyrophenone, 2,2-dimethyl-2'-trifluoromethyl-
EINECS	Contact for details

Quality Control

Our production of 2,2-Dimethyl-2'-Trifluoromethylbutyrophenone adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for fine chemical and pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.