Description

2,2-Dimethyl-2'-Fluorobutyrophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in the strategic incorporation of both a sterically hindered ketone moiety and a fluorine atom, enabling precise control over molecular architecture and properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in medicinal chemistry for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially in CNS and anti-inflammatory research.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the fluorine atom enhances bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display and lighting materials.
• Polymer Modification: Acts as a functional monomer or cross-linking agent to introduce specific properties into specialty polymers.
• Organic Synthesis Building Block: Employed in Friedel-Crafts acylation, Grignard reactions, and reduction sequences to create complex, fluorinated structures.
• Chemical Research & Development: Utilized in academic and industrial labs for methodological studies and exploring new fluorination chemistry pathways.

Basic Information

Product Name	2,2-Dimethyl-2'-Fluorobutyrophenone
CAS No.	898765-76-9
Molecular Formula	C12H15FO
Molecular Weight	194.25 g/mol
Synonyms	2'-Fluoro-2,2-dimethylbutyrophenone; 1-(2-Fluorophenyl)-2,2-dimethyl-1-butanone; α,α-Dimethyl-2-fluorohydrocinnamone; 2-Fluoro-α,α-dimethylhydrocinnamaldehyde; Butyrophenone, 2,2-dimethyl-2'-fluoro-; 2,2-Dimethyl-1-(2-fluorophenyl)butan-1-one
EINECS	Contact for details

Quality Control

Our 2,2-Dimethyl-2'-Fluorobutyrophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed to prevent moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.