Description

3,3-Dimethyl-3',4',5'-Trifluorobutyrophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors where the introduction of fluorine atoms is crucial for modulating biological activity and metabolic stability. Industries that require this product include pharmaceutical R&D for active pharmaceutical ingredient (API) synthesis, agrochemical manufacturing for novel crop protection agents, and advanced material science for specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing fluorinated active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl and fluorine substituents enhance efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens used in high-performance liquid crystal displays (LCDs) and optical devices.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport or host materials for OLED fabrication due to its stable aromatic-fluorine system.
• Advanced Polymer Monomers: Acts as a specialty monomer for introducing fluorine functionality into high-performance polymers, improving chemical resistance and thermal stability.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and creating novel chemical entities.

Basic Information

Product Name	3,3-Dimethyl-3',4',5'-Trifluorobutyrophenone
CAS No.	898765-00-9
Molecular Formula	C12H13F3O
Molecular Weight	230.23 g/mol
Synonyms	1-(3,4,5-Trifluorophenyl)-3,3-dimethylbutan-1-one; 3,3-Dimethyl-1-(3,4,5-trifluorophenyl)butan-1-one; 3',4',5'-Trifluoro-3,3-dimethylbutyrophenone; Butyrophenone, 3,3-dimethyl-3',4',5'-trifluoro-; TF-DMBP; Trifluorodimethylbutyrophenone
EINECS	Contact for details

Quality Control

Our 3,3-Dimethyl-3',4',5'-Trifluorobutyrophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP guidelines where applicable, ensuring the material is suitable for demanding applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.