Description

2',4'-Difluoro-3,3-Dimethylbutyrophenone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its value lies in its unique molecular structure, which serves as a critical precursor for the development of complex pharmaceutical intermediates and agrochemical active ingredients. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality fluorinated synthons for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key fluorinated building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where the difluoro and dimethyl groups impart desirable biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to introduce complex fluorinated side chains into target molecules.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D labs for exploring new fluorination methodologies and constructing novel fluorinated heterocycles.
• Material Science: Employed in the development of specialty polymers and coatings where fluorinated aromatic units enhance chemical resistance and thermal stability.

Basic Information

Product Name	2',4'-Difluoro-3,3-Dimethylbutyrophenone
CAS No.	898764-94-8
Molecular Formula	C12H14F2O
Molecular Weight	212.24 g/mol
Synonyms	1-(2,4-Difluorophenyl)-3,3-dimethylbutan-1-one; 3,3-Dimethyl-1-(2,4-difluorophenyl)butan-1-one; 2,4-Difluoro-3,3-dimethylbutyrophenone; α,α-Dimethyl-2,4-difluorohydrocinnamophenone; Butan-1-one, 1-(2,4-difluorophenyl)-3,3-dimethyl-; Difluorodimethylbutyrophenone
EINECS	Contact for details

Quality Control

Our 2',4'-Difluoro-3,3-Dimethylbutyrophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for demanding pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.