Description

4'-Chloro-3,3-Dimethyl-2'-Fluorobutyrophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular architecture, which incorporates both halogen and fluorine substituents, making it a versatile precursor for constructing complex pharmacophores and agrochemical intermediates. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with tailored properties.
• Chemical Biology Probes: Utilized in the creation of fluorinated probes and tags for studying biological mechanisms and enzyme interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.
• Academic Research: Employed in university and institutional labs for methodological studies in fluorination and cross-coupling chemistry.

Basic Information

Item	Details
Product Name	4'-Chloro-3,3-Dimethyl-2'-Fluorobutyrophenone
CAS No.	898764-82-4
Molecular Formula	C12H14ClFO
Molecular Weight	228.69 g/mol
Synonyms	1-(4-Chloro-2-fluorophenyl)-3,3-dimethylbutan-1-one; 2-Fluoro-4-chloro-α,α-dimethylbenzenebutanone; 3,3-Dimethyl-1-(2-fluoro-4-chlorophenyl)butan-1-one; 4-Chloro-2-fluoro-α,α-dimethylhydrocinnamophenone; Butyrophenone, 4'-chloro-3,3-dimethyl-2'-fluoro-; 898764-82-4; 4'-Chloro-3,3-dimethyl-2'-fluorobutyrophenone
EINECS	Contact for details

Quality Control

Every batch of 4'-Chloro-3,3-Dimethyl-2'-Fluorobutyrophenone is produced under strict quality management protocols. Our products undergo rigorous quality testing, including HPLC, GC, and NMR analysis, to ensure high purity and consistency for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.