Description

3'-Chloro-3,3-Dimethyl-5'-Fluorobutyrophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the aromatic ring, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated aromatic moiety.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and liquid crystals where fluorine incorporation enhances thermal stability and chemical resistance.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic & Industrial R&D: Used in exploratory chemistry within university laboratories and corporate R&D centers for method development and discovery chemistry.

Basic Information

Product Name	3'-Chloro-3,3-Dimethyl-5'-Fluorobutyrophenone
CAS No.	898764-80-2
Molecular Formula	C12H14ClFO
Molecular Weight	228.69 g/mol
Synonyms	1-(3-Chloro-5-fluorophenyl)-3,3-dimethylbutan-1-one; 3,3-Dimethyl-1-(3-chloro-5-fluorophenyl)butan-1-one; 5'-Fluoro-3'-chloro-3,3-dimethylbutyrophenone; Butan-1-one, 1-(3-chloro-5-fluorophenyl)-3,3-dimethyl-; 3-Chloro-5-fluoro-3,3-dimethylbutyrophenone
EINECS	Contact for details

Quality Control

We supply 3'-Chloro-3,3-Dimethyl-5'-Fluorobutyrophenone in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We adhere to a cGMP-compliant quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.