Description

4'-Bromo-3,3-dimethyl-2'-fluorobutyrophenone is a specialized fluorinated and brominated aromatic ketone building block. This compound is valued for its unique molecular architecture, which makes it a critical intermediate in advanced organic synthesis, particularly for constructing complex pharmacophores. It is primarily needed by research and development chemists and process development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the fluorine and bromine substituents for bioactivity.
• Material Science Research: Serves as a monomer or building block for developing specialty polymers and advanced organic materials with specific electronic properties.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized as a scaffold for creating molecular probes to study enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	4'-Bromo-3,3-dimethyl-2'-fluorobutyrophenone
CAS No.	898764-78-8
Molecular Formula	C12H14BrFO
Molecular Weight	273.14 g/mol
Synonyms	2'-Fluoro-4'-bromo-3,3-dimethylbutyrophenone; 1-(4-Bromo-2-fluorophenyl)-3,3-dimethylbutan-1-one; 3,3-Dimethyl-1-(4-bromo-2-fluorophenyl)butan-1-one; 4'-Bromo-2'-fluoro-3,3-dimethylbutyrophenone; α,α-Dimethyl-4-bromo-2-fluorohydrocinnamophenone; Butan-1-one, 1-(4-bromo-2-fluorophenyl)-3,3-dimethyl-; 898764-78-8
EINECS	Contact for details

Quality Control

Our 4'-Bromo-3,3-dimethyl-2'-fluorobutyrophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.