Description

3,3-Dimethyl-3'-Trifluoromethylbutyrophenone is a high-value, fluorinated aromatic ketone building block. This compound is prized for its unique structural features, combining a sterically hindered ketone with a trifluoromethylphenyl group, which are critical for modulating the physicochemical properties of advanced materials and active molecules. It is primarily sought by R&D and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel compounds requiring enhanced metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for introducing the trifluoromethyl group to improve drug-like properties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the CF3 group contributes to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic semiconductors and liquid crystal molecules for display technologies.
• Polymer & Resin Modifier: Incorporated as a monomer or additive to create specialty polymers with tailored thermal, optical, or surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, Grignard additions, and reductions to construct complex molecular architectures in academic and industrial research.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine substitution on reaction mechanisms and material performance.

Basic Information

Product Name	3,3-Dimethyl-3'-Trifluoromethylbutyrophenone
CAS No.	898764-74-4
Molecular Formula	C13H15F3O
Molecular Weight	244.26 g/mol
Synonyms	1-[3-(Trifluoromethyl)phenyl]-3,3-dimethylbutan-1-one; 3,3-Dimethyl-1-[3-(trifluoromethyl)phenyl]-1-butanone; 3,3-Dimethyl-3'-trifluoromethylbutyrophenone; 3'-Trifluoromethyl-3,3-dimethylbutyrophenone; α,α-Dimethyl-3'-(trifluoromethyl)butyrophenone; 3,3-Dimethyl-3'-trifluoromethylpropiophenone (common misnomer); TFMPB derivative; Butyrophenone, 3,3-dimethyl-3'-trifluoromethyl-
EINECS	Contact for details

Quality Control

Our 3,3-Dimethyl-3'-Trifluoromethylbutyrophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.