Description

4'-Chloro-3,3-Dimethyl-3'-Fluorobutyrophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex, biologically active molecules, particularly within the pharmaceutical sector. It is primarily needed by research and development chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aryl ketone motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the chloro-fluoro substitution pattern confers specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of novel organic electronic materials and liquid crystals due to its specific halogenated structure.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.
• Academic and Industrial R&D: Utilized in research laboratories for methodological studies in fluorination chemistry and cross-coupling reactions.

Basic Information

Item	Detail
Product Name	4'-Chloro-3,3-Dimethyl-3'-Fluorobutyrophenone
CAS No.	898764-64-2
Molecular Formula	C12H14ClFO
Molecular Weight	228.69 g/mol
Synonyms	1-(4-Chloro-3-fluorophenyl)-3,3-dimethylbutan-1-one; 3,3-Dimethyl-1-(4-chloro-3-fluorophenyl)butan-1-one; 4-Chloro-3-fluoro-3,3-dimethylbutyrophenone; Butan-1-one, 1-(4-chloro-3-fluorophenyl)-3,3-dimethyl-; 898764-64-2; 4'-Chloro-3'-fluoro-3,3-dimethylbutyrophenone
EINECS	Contact for details

Quality Control

Our 4'-Chloro-3,3-Dimethyl-3'-Fluorobutyrophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.