Description

3-Phenyl-2'-Trifluoromethylpropiophenone is a high-value fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethyl group, enabling the development of novel compounds with enhanced metabolic stability and lipophilicity. This intermediate is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and fungicides, where the CF3 group can improve weather resistance and biological activity.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals that require fluorinated aromatic components for specific thermal or optical properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, carbonyl chemistry, and as a precursor for chiral ligands and catalysts in asymmetric synthesis.
• Fluorine Chemistry Research: An essential compound for academic and industrial research focused on introducing trifluoromethyl groups into complex molecular architectures.

Basic Information

Product Name	3-Phenyl-2'-Trifluoromethylpropiophenone
CAS No.	898764-51-7
Molecular Formula	C16H13F3O
Molecular Weight	278.27 g/mol
Synonyms	1-(3-Phenylpropanoyl)-2-(trifluoromethyl)benzene; 2'-Trifluoromethyl-3-phenylpropiophenone; 3-Phenyl-1-[2-(trifluoromethyl)phenyl]propan-1-one; Propiophenone, 3-phenyl-2'-(trifluoromethyl)-; α-Ethyl-2'-(trifluoromethyl)benzhydryl ketone
EINECS	Contact for details

Quality Control

Our 3-Phenyl-2'-Trifluoromethylpropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which could affect stability and handling properties. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.