Description

4'-Bromo-3'-Fluoro-3-Phenylpropiophenone is a high-value, multi-functional organic intermediate characterized by its distinct halogenated aromatic structure. This compound matters for its role as a versatile building block in advanced organic synthesis, enabling the introduction of both bromo and fluoro substituents in a single molecular framework. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex active molecules and novel materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory conditions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging the bioactivity of its halogenated phenylpropiophenone core.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing advanced organic electronic materials and liquid crystal compounds.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine introduction on molecular properties like metabolic stability and lipophilicity in drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied to custom synthesis facilities for the production of proprietary compounds and specialty chemicals.

Basic Information

Product Name	4'-Bromo-3'-Fluoro-3-Phenylpropiophenone
CAS No.	898764-36-8
Molecular Formula	C15H12BrFO
Molecular Weight	307.16 g/mol
Synonyms	1-(4-Bromo-3-fluorophenyl)-3-phenylpropan-1-one; 3-Phenyl-1-(4-bromo-3-fluorophenyl)propan-1-one; 4'-Bromo-3'-fluorodihydrochalcone; 898764-36-8; 4-Bromo-3-fluoro-3-phenylpropiophenone; 1-(4-Bromo-3-fluorophenyl)-3-phenyl-1-propanone
EINECS	Contact for details

Quality Control

Our 4'-Bromo-3'-Fluoro-3-Phenylpropiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.