Description

3-Chloro-3'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-5-Fluorobenzophenone is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and benzophenone structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, custom synthesis providers, and fine chemical manufacturers seeking a reliable, high-quality building block for complex organic synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel drug candidates, especially those with spirocyclic architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for discovering new therapeutic agents.
• Custom Synthesis & Contract Manufacturing: An essential starting material for contract research organizations (CROs) and CDMOs producing complex molecules for clinical trials.
• API Development: Employed in the development and scale-up processes for new active pharmaceutical ingredients, particularly in neurological and psychiatric drug categories.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical analysis.
• Academic Research: Used in university and institutional labs for advanced studies in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Product Name	3-Chloro-3'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-5-Fluorobenzophenone
CAS No.	898762-13-5
Molecular Formula	C25H27ClFNO3
Molecular Weight	443.94 g/mol
Synonyms	5-Fluoro-3'-chloro-3-[[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]benzophenone; 3-Chloro-3'-(8-(1,4-dioxa-8-azaspiro[4.5]decyl)methyl)-5-fluorobenzophenone; 898762-13-5; Benzophenone, 3-chloro-3'-[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-5-fluoro-; 3'-Chloro-5-fluoro-3-((1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl)benzophenone
EINECS	Contact for details

Quality Control

Our 3-Chloro-3'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-5-Fluorobenzophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring a reliable supply for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.