Description

3-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-4'-Fluorobenzophenone is a sophisticated organic building block featuring a benzophenone core functionalized with a fluorinated aromatic ring and a protected amine spirocycle. This compound matters for its role as a key intermediate in the synthesis of complex pharmaceutical molecules, particularly in the development of central nervous system (CNS) active drugs and other bioactive compounds. Pharmaceutical R&D teams, agrochemical innovators, and advanced material scientists need this high-purity intermediate to enable critical synthetic pathways and accelerate their discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially those targeting neurological disorders.
• Agrochemical Research: Used in the development of advanced active ingredients for crop protection products.
• Chemical Biology & Proteomics: Serves as a precursor for photoaffinity labeling probes and other molecular tools due to its benzophenone moiety.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers with specific optical or electronic properties.
• Academic & Contract Research: Essential for organic synthesis research in universities and CROs (Contract Research Organizations) exploring new heterocyclic chemistry.
• Scale-Up & Process Chemistry: Supplied in development and pilot-scale quantities to support route optimization and pre-clinical manufacturing.

Basic Information

Product Name	3-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-4'-Fluorobenzophenone
CAS No.	898761-79-0
Molecular Formula	C21H22FNO3
Molecular Weight	355.41 g/mol
Synonyms	4'-Fluoro-3-[(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl]benzophenone; 3-[(8-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl]-4'-fluorobenzophenone; 898761-79-0; 4'-Fluoro-3-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)benzophenone; Benzophenone, 4'-fluoro-3-[(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl]-
EINECS	Contact for details

Quality Control

Every batch of 3-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-4'-Fluorobenzophenone is manufactured under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with the high-purity standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.