Description

4'-(1,3-Dioxolan-2-Yl)-3,4,5-Trifluorobenzophenone is a high-value fluorinated benzophenone derivative featuring a protected carbonyl group, making it a critical advanced intermediate in modern synthetic chemistry. Its unique structure provides a versatile scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce specific fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics where the trifluoromethyl and benzophenone groups are pharmacologically relevant.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where fluorination enhances bioavailability, metabolic stability, and binding affinity.
• Liquid Crystal & OLED Material Precursor: Serves as an intermediate in the manufacture of fluorinated organic electronic materials for displays and lighting applications, contributing to improved performance and stability.
• Organic Synthesis & Chemical Research: Employed in academic and industrial R&D labs as a versatile reagent for Suzuki-Miyaura cross-coupling, nucleophilic aromatic substitution, and other reactions to create complex aromatic systems.
• Polymer Chemistry: Acts as a monomer or functionalization agent for synthesizing specialty polymers with enhanced thermal, chemical, or optical properties.

Basic Information

Product Name	4'-(1,3-Dioxolan-2-Yl)-3,4,5-Trifluorobenzophenone
CAS No.	898760-82-2
Molecular Formula	C₁₆H₁₁F₃O₃
Molecular Weight	308.25 g/mol
Synonyms	3,4,5-Trifluoro-4'-(1,3-dioxolan-2-yl)benzophenone; 2-[4-(3,4,5-Trifluorobenzoyl)phenyl]-1,3-dioxolane; 4'-(1,3-Dioxolan-2-yl)-3,4,5-trifluorobenzophenone; Benzophenone, 4'-(1,3-dioxolan-2-yl)-3,4,5-trifluoro-; (3,4,5-Trifluorophenyl)[4-(1,3-dioxolan-2-yl)phenyl]methanone
EINECS	Contact for details

Quality Control

Our 4'-(1,3-Dioxolan-2-Yl)-3,4,5-Trifluorobenzophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP or research-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to maintain product integrity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.