Description

2-(3,5-Difluorobenzoyl)Oxazole is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines an oxazole ring with a difluorinated benzoyl group, making it a versatile precursor for constructing complex pharmacophores. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in the development of fluorinated drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the introduction of fluorine atoms enhances biological activity and environmental stability.
• Material Science Research: Serves as a building block for novel organic electronic materials, including OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis, facilitating challenging cross-coupling and fluorination reactions.
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on understanding the effects of fluorine substitution on molecular properties and reactivity.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	2-(3,5-Difluorobenzoyl)Oxazole
CAS No.	898760-50-4
Molecular Formula	C10H5F2NO2
Molecular Weight	209.15 g/mol
Synonyms	2-(3,5-Difluorobenzoyl)-1,3-oxazole; 3,5-Difluoro-2-oxazolephenylmethanone; Oxazole, 2-(3,5-difluorobenzoyl)-; 898760-50-4; 2-(3,5-Difluorobenzoyl)oxazole; (3,5-Difluorophenyl)(oxazol-2-yl)methanone
EINECS	Contact for details

Quality Control

Every batch of 2-(3,5-Difluorobenzoyl)Oxazole is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, which include data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the exacting standards required for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent potential degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.