Description

3,4-Difluoro-3'-(1,3-Dioxolan-2-Yl)Benzophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzophenone core functionalized with fluorine and a protected aldehyde group. This compound matters for its critical role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. Pharmaceutical R&D and manufacturing teams need this precise chemical to enable efficient, scalable synthetic routes, ensuring the production of novel therapeutics with high efficacy and purity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in medicinal chemistry programs focused on fluorine-containing molecules.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the difluoro and benzophenone motifs contribute to biological activity.
• Material Science Research: Serves as a monomer or functional additive in the development of specialty polymers and advanced organic electronic materials.
• Organic Synthesis Building Block: Employed in academic and industrial laboratories for constructing complex molecular architectures, leveraging the reactivity of the dioxolane-protected carbonyl group.
• Liquid Crystal & OLED Development: Acts as a core structure in the design of fluorinated compounds for display and lighting technologies.

Basic Information

Product Name	3,4-Difluoro-3'-(1,3-Dioxolan-2-Yl)Benzophenone
CAS No.	898759-65-4
Molecular Formula	C₁₆H₁₂F₂O₃
Molecular Weight	290.26 g/mol
Synonyms	2-[3-(3,4-Difluorobenzoyl)phenyl]-1,3-dioxolane; 3,4-Difluoro-3'-(1,3-dioxolan-2-yl)benzophenone; (3,4-Difluorophenyl)[3-(1,3-dioxolan-2-yl)phenyl]methanone; 3-(1,3-Dioxolan-2-yl)-3',4'-difluorobenzophenone; 898759-65-4; Benzophenone, 3,4-difluoro-3'-(1,3-dioxolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-3'-(1,3-Dioxolan-2-Yl)Benzophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting full specifications are available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.