Description

3,5-Difluoro-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone is a high-value, multifunctional organic intermediate featuring a benzophenone core with a protected amine spirocycle. This compound matters for its role as a critical building block in the synthesis of complex molecules, offering a unique combination of a photoreactive ketone and a masked primary amine for selective derivatization. Pharmaceutical and advanced material researchers need it for developing novel active pharmaceutical ingredients (APIs), particularly in neurological and oncological research, as well as for creating specialty polymers and photoactive materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for central nervous system (CNS) and oncology targets, leveraging its spirocyclic amine and benzophenone moieties.
• Photoaffinity Labeling Probes: Utilized in chemical biology and proteomics research due to the benzophenone group's ability to form covalent bonds with target proteins upon UV irradiation, enabling target identification.
• Polymer Science & Advanced Materials: Serves as a monomer or cross-linking agent for developing specialty polymers with tailored thermal, optical, or mechanical properties.
• Ligand & Catalyst Development: The protected amine spirocycle acts as a sophisticated ligand precursor for asymmetric catalysis and metal-organic framework (MOF) synthesis.
• Agrochemical Research: Employed in the discovery and development of new generation herbicides and fungicides with novel modes of action.
• Academic & Contract Research: Essential for medicinal chemistry programs and methodological studies in organic synthesis at research institutions and CROs.

Basic Information

Item	Details
Product Name	3,5-Difluoro-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone
CAS No.	898758-49-1
Molecular Formula	C25H27F2NO3
Molecular Weight	427.49 g/mol
Synonyms	4'-[8-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-3,5-difluorobenzophenone; 3,5-Difluoro-4'-(1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl)benzophenone (common misnomer); Benzophenone, 3,5-difluoro-4'-[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-; Spirocyclic Amine-Protected Difluorobenzophenone; DFAB-Spiroketal Intermediate; Photoaffinity Labeling Intermediate CAS 898758-49-1; API Intermediate 898758-49-1
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot undergoes comprehensive analytical characterization including HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed in a desiccated environment. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.