Description

2-Chloro-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-4-Fluorobenzophenone is a sophisticated organic intermediate featuring a benzophenone core functionalized with halogen and spirocyclic acetal-protected amine moieties. This compound is valued for its role as a key building block in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for creating novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Chemical Research & Development: Used as a versatile building block for constructing complex molecular architectures in medicinal chemistry and process chemistry.
• Protease Inhibitor Synthesis: The structural elements suggest potential application in the development of protease or kinase inhibitor libraries.
• Advanced Material Precursor: Can be utilized in the development of specialty polymers or organic electronic materials requiring specific photoactive or charge-transfer properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions where applicable.

Basic Information

Item	Detail
Product Name	2-Chloro-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-4-Fluorobenzophenone
CAS No.	898758-19-5
Molecular Formula	C21H21ClFNO3
Molecular Weight	389.85 g/mol
Synonyms	4-Fluoro-2-chloro-4'-[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]benzophenone; 2-Chloro-4'-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylmethyl)-4-fluorobenzophenone; 898758-19-5; Benzophenone, 2-chloro-4'-[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-4-fluoro-; 4-Fluoro-2-chloro-4'-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylmethyl)benzophenone
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-4-Fluorobenzophenone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects with quality standards suitable for research use through to cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.