Description

4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-4-Trifluoromethylbenzophenone is a high-value, multifunctional organic intermediate featuring a benzophenone core modified with a spirocyclic acetal-protected amine and a trifluoromethyl group. This unique molecular architecture makes it a critical building block for the synthesis of advanced pharmaceutical compounds and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Chemical Biology & Proteomics: Serves as a precursor for photoaffinity labeling probes and other tool compounds due to the benzophenone moiety's ability to form covalent bonds upon UV irradiation.
• Material Science Research: Investigated as a monomer or cross-linking agent for the development of specialty polymers with unique optical or surface properties.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing complex, nitrogen- and oxygen-containing heterocycles via manipulation of the protected amine and ketal groups.

Basic Information

Product Name	4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-4-Trifluoromethylbenzophenone
CAS No.	898758-14-0
Molecular Formula	C22H22F3NO3
Molecular Weight	405.41 g/mol
Synonyms	4-Trifluoromethyl-4'-[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]benzophenone; 1,4-Dioxa-8-azaspiro[4.5]decane, 8-[[4-(4-(trifluoromethyl)benzoyl)phenyl]methyl]-; 8-[[4-[4-(Trifluoromethyl)benzoyl]phenyl]methyl]-1,4-dioxa-8-azaspiro[4.5]decane; 4'-(1,4-Dioxa-8-azaspiro[4.5]dec-8-ylmethyl)-4-(trifluoromethyl)benzophenone; (4-(Trifluoromethyl)phenyl)(4-((1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl)phenyl)methanone
EINECS	Contact for details

Quality Control

Our production of 4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-4-Trifluoromethylbenzophenone adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with customer specifications and relevant ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.