Description

4-Chloro-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-3-Fluorobenzophenone is a high-value, complex organic intermediate featuring a benzophenone core functionalized with halogen and spirocyclic amine-protecting groups. This compound is critical for its role in advanced pharmaceutical synthesis, particularly as a key building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging its fluorinated benzophenone structure.
• Chemical Biology Probe: Acts as a scaffold for creating photoaffinity labels or PROTACs (Proteolysis Targeting Chimeras) due to its benzophenone moiety.
• Material Science: Potential monomer or cross-linking agent for advanced polymers with specific optical or electronic properties.
• Academic & Contract Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	4-Chloro-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-3-Fluorobenzophenone
CAS No.	898758-02-6
Molecular Formula	C23H25ClFNO3
Molecular Weight	417.90 g/mol
Synonyms	3-Fluoro-4'-[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-4-chlorobenzophenone; 4-Chloro-3-fluoro-4'-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)benzophenone; 898758-02-6; 4-Chloro-4'-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-3-fluorobenzophenone; 3-Fluoro-4-chloro-4'-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)benzophenone
EINECS	Contact for details

Quality Control

Our 4-Chloro-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-3-Fluorobenzophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container must be kept tightly sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.