Description

3'-Bromo-4'-Chloro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated aromatic ketone structure with a protected diol functionality. This compound matters as a critical building block in modern organic synthesis, enabling the development of complex, biologically active molecules with precise stereochemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of novel drug candidates, especially those targeting neurological pathways.
• Organic Synthesis Building Block: Used in complex organic reactions, including cross-coupling and nucleophilic substitution, to introduce specific halogenated aryl ketone motifs.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Chemistry Development: Utilized for scaling up synthetic routes from laboratory to pilot plant scale under GMP-like conditions.
• Chemical Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in API manufacturing.
• Academic Research: Used in university laboratories for investigating new synthetic methodologies involving protected functional groups.

Basic Information

Product Name	3'-Bromo-4'-Chloro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone
CAS No.	898757-23-8
Molecular Formula	C₁₆H₂₀BrClO₃
Molecular Weight	375.69 g/mol
Synonyms	2-(3-Bromo-4-chlorophenyl)-1-[4-(5,5-dimethyl-1,3-dioxan-2-yl)butyl]ethanone; 1-[4-(5,5-Dimethyl-1,3-dioxan-2-yl)butyl]-2-(3-bromo-4-chlorophenyl)ethan-1-one; 3-Bromo-4-chloro-4'-(5,5-dimethyl-1,3-dioxan-2-yl)butyrophenone; Butyrophenone, 3'-bromo-4'-chloro-4-(5,5-dimethyl-1,3-dioxan-2-yl)-; 898757-23-8; Bromochloro Dimethyldioxanyl Butyrophenone; BCDB Intermediate
EINECS	Contact for details

Quality Control

Our 3'-Bromo-4'-Chloro-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with ICH guidelines, and we support customer audits and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.