Description

4-(Azetidinomethyl)Phenyl Cyclobutyl Ketone is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular architecture that combines an azetidine moiety with a cyclobutyl ketone group. This compound is of significant value in modern medicinal chemistry for constructing novel bioactive scaffolds, particularly in the development of targeted small-molecule therapeutics. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of new chemical entities (NCEs) for oncology, central nervous system (CNS), and anti-inflammatory drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the pharmacokinetic and pharmacodynamic properties of lead compounds.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of bifunctional molecules for targeted protein degradation.
• Kinase Inhibitor Synthesis: Incorporated into the core structure of potential kinase inhibitors due to the conformational constraint offered by the cyclobutyl ring.
• Chemical Biology Probes: Utilized in the creation of tool compounds for investigating enzyme function and cellular signaling mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring this specific, high-value molecular fragment.

Basic Information

Product Name	4-(Azetidinomethyl)Phenyl Cyclobutyl Ketone
CAS No.	898757-12-5
Molecular Formula	C15H19NO
Molecular Weight	229.32 g/mol
Synonyms	4-(Azetidin-1-ylmethyl)phenyl cyclobutyl ketone; 1-[4-(Azetidin-1-ylmethyl)phenyl]cyclobutan-1-one; Cyclobutanone, 1-[4-(1-azetidinylmethyl)phenyl]-; 4-(1-Azetidinylmethyl)benzonitrile cyclobutyl ketone; Ketone, 4-(azetidinomethyl)phenyl cyclobutyl; [4-(Azetidin-1-ylmethyl)phenyl](cyclobutyl)methanone
EINECS	Contact for details

Quality Control

Our 4-(Azetidinomethyl)Phenyl Cyclobutyl Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, containers should be kept sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.