Description

4'-Azetidinomethyl-3,4,5-Trifluorobenzophenone is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluorobenzophenone core linked to an azetidine moiety. This compound matters for its critical role as a key building block in the synthesis of novel, potent active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high specificity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, especially within oncology and central nervous system (CNS) domains.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug molecules and investigational new drugs (INDs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Used in the production of active pharmaceutical ingredients (APIs) that leverage the metabolic stability and lipophilicity imparted by the trifluoromethyl groups.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials.
• Bioconjugation & Probe Development: Potential use in creating chemical probes or conjugates for biological target identification and validation.

Basic Information

Product Name	4'-Azetidinomethyl-3,4,5-Trifluorobenzophenone
CAS No.	898757-08-9
Molecular Formula	C17H15F3NO
Molecular Weight	306.31 g/mol
Synonyms	3,4,5-Trifluoro-4'-(azetidin-1-ylmethyl)benzophenone; 1-[(3,4,5-Trifluorobenzoyl)benzyl]azetidine; 4'-(Azetidin-1-ylmethyl)-3,4,5-trifluorobenzophenone; (4-(Azetidin-1-ylmethyl)phenyl)(3,4,5-trifluorophenyl)methanone; Azetidine, 1-[[4-(3,4,5-trifluorobenzoyl)phenyl]methyl]-; 898757-08-9; 4'-(Azetidinomethyl)-3,4,5-trifluorobenzophenone
EINECS	Contact for details

Quality Control

Our 4'-Azetidinomethyl-3,4,5-Trifluorobenzophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with stringent industry standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.