Description

2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-4'-Fluorobenzophenone is a sophisticated organic intermediate featuring a benzophenone core functionalized with a fluorinated aromatic ring and a spirocyclic acetal-protected amine moiety. This compound matters for its role as a critical building block in the synthesis of complex pharmaceutical agents, particularly in developing central nervous system (CNS) and receptor-targeted therapies. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in advanced medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for neurological and psychiatric drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique spirocyclic and fluorinated structure.
• Protecting Group Chemistry: The 1,4-dioxa-8-azaspiro[4.5]decyl group serves as a protected amine functionality, useful in multi-step synthetic sequences.
• Ligand and Probe Development: Potential use in creating high-affinity ligands or fluorescent probes for biological target identification and validation.
• Process Chemistry & Scale-Up: Serves as a defined intermediate for process development and GMP manufacturing of complex drug molecules.

Basic Information

Product Name	2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-4'-Fluorobenzophenone
CAS No.	898756-05-3
Molecular Formula	C21H22FNO3
Molecular Weight	355.41 g/mol
Synonyms	4'-Fluoro-2-[(8-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl))methyl]benzophenone; 2-[(8-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl))methyl]-4'-fluorobenzophenone; 4'-Fluoro-2-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)benzophenone; 898756-05-3; Benzophenone, 2-[(8-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl))methyl]-4'-fluoro-
EINECS	Contact for details

Quality Control

Our 2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-4'-Fluorobenzophenone is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.