Description

4'-Bromo-2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapies. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities (NCEs).

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Process Chemistry Development: Serves as a standardized building block for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Employed in organic synthesis and methodology development due to its unique spirocyclic and benzophenone functionalities.
• Bioconjugation & Probe Synthesis: Potential use in creating photoaffinity labels or molecular probes for biochemical assays, leveraging the benzophenone moiety.

Basic Information

Product Name	4'-Bromo-2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone
CAS No.	898755-99-2
Molecular Formula	C21H22BrNO3
Molecular Weight	416.31 g/mol
Synonyms	4'-Bromo-2-[(8-(1,4-dioxa-8-azaspiro[4.5]decyl))methyl]benzophenone; 2-[(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-4'-bromobenzophenone; 4'-Bromo-2-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)benzophenone; Benzophenone, 4'-bromo-2-[8-(1,4-dioxa-8-azaspiro[4.5]decyl)methyl]-; 898755-99-2; Spirocyclic benzophenone intermediate; Bromo-substituted benzophenone derivative.
EINECS	Contact for details

Quality Control

Our 4'-Bromo-2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.