Description

Bis-3',5'-Trifluoromethyl-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone is a specialized fluorinated organic intermediate featuring a protected carbonyl group. This compound matters for its role as a key building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, where its unique trifluoromethyl and acetal-protected ketone functionalities enable precise molecular construction.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials with specific optical or electronic properties.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands or organocatalysts for asymmetric synthesis, leveraging its rigid dioxane structure.
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination reactions and studying the influence of multiple fluorine atoms on chemical reactivity and physical properties.

Basic Information

Product Name	Bis-3',5'-Trifluoromethyl-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone
CAS No.	898755-91-4
Molecular Formula	C20H22F6O3
Molecular Weight	424.38 g/mol
Synonyms	4,4'-(5,5-Dimethyl-1,3-dioxan-2-yl)bis(3,5-bis(trifluoromethyl)propiophenone); 1,1'-[2-(5,5-Dimethyl-1,3-dioxan-2-yl)-1,4-butanediyl]bis[3,5-bis(trifluoromethyl)benzene]; Bis(3,5-bis(trifluoromethyl)phenyl)-4-(5,5-dimethyl-1,3-dioxan-2-yl)butan-1-one; Acetal-protected Bis(trifluoromethyl) Butyrophenone Derivative
EINECS	Contact for details

Quality Control

Our Bis-3',5'-Trifluoromethyl-4-(5,5-Dimethyl-1,3-Dioxan-2-Yl)Butyrophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed to prevent moisture absorption and potential decomposition of the acetal protecting group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.