Description

3-(2,6-Dimethylphenyl)-3',4',5'-Trifluoropropiophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular architecture, which combines a sterically hindered dimethylphenyl group with a trifluorinated propiophenone moiety, enabling precise modifications in complex molecular frameworks. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine-tuning physicochemical properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or requiring enhanced metabolic stability and lipophilicity.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms and aromatic structure contribute to biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis Reagent: Employed in cross-coupling reactions, Friedel-Crafts acylations, and as a precursor for chiral ligands or catalysts in asymmetric synthesis.
• Fluorine Chemistry Studies: An important compound for academic and industrial research into the effects of polyfluorination on molecular conformation and reactivity.

Basic Information

Product Name	3-(2,6-Dimethylphenyl)-3',4',5'-Trifluoropropiophenone
CAS No.	898755-34-5
Molecular Formula	C17H15F3O
Molecular Weight	292.30 g/mol
Synonyms	1-[3,4,5-Trifluorophenyl]-3-(2,6-dimethylphenyl)-1-propanone; 3',4',5'-Trifluoro-3-(2,6-dimethylphenyl)propiophenone; 3-(2,6-Dimethylphenyl)-1-(3,4,5-trifluorophenyl)propan-1-one; 2,6-Dimethyl-3',4',5'-trifluoropropiophenone; Propiophenone, 3-(2,6-dimethylphenyl)-3',4',5'-trifluoro-; 898755-34-5; (3,4,5-Trifluorophenyl)(2,6-dimethylphenyl)ethyl ketone
EINECS	Contact for details

Quality Control

Our 3-(2,6-Dimethylphenyl)-3',4',5'-Trifluoropropiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to quality ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.